This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.
Vitamin D – Immune System Support to the Next Level
Activation of the beneficial health-protective activities of white blood cells is a crucial event in the rapid response that is often required of the immune system. Research published in the Journal of Immunology has shown activated vitamin D to be a powerful stimulant to the white blood cells that mount the first line of chemical defense during the initial phases of a heightened immune response.24 This finding has been confirmed more recently by data published in the FASEB Journal and in Science.25,26 Both studies illustrate the effectiveness of vitamin D in maintaining optimal immune responses by targeting the activities of immune components.
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Vitamin D – Run Faster, Jump Higher!
24. Wang T-T, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, Tavera- Mendoza L, Lin R, Hanrahan JH, Mader S, White JH. Cutting edge: 1,25-Dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004;173:2909-2912.
25. Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J 2005;19:1067-1077.
26. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zugel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006;311:1770-1773.