Essential Brain Nourishment: PhospatidylSerine

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each week, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Essential Brain Nourishment: PhospatidylSerine

While DHA is the major fatty acid in the brain, PhospatidylSerine is the major structural component of brain cell membranes. PhospatidylSerine also is a precursor to phosphatidylcholine, another structural component of cell membranes. Within the neuronal cell membrane, PhospatidylSerine is required in order for the chemical events through which one neuron communicates with another to occur. Enhancing the concentration of PhospatidylSerine in neurons increases the speed and accuracy of cell-to-cell communication – effects that manifest as enhanced performance on tasks that test learning ability and short-term memory. PhospatidylSerine facilitates the formation of new memories (learning) and their retrieval.

In a “gold standard” randomized placebo-controlled clinical trial, daily dietary supplementation with 300 mg of PhospatidylSerine has been found to produce significant improvements in attention, vigilance, short-term recall, immediate memory, vocabulary skills and the ability to recall words in men and women over 60 years of age.9 In other studies, moderate losses of the abilities to concentrate, focus attention, learn and perform daily activities were somewhat reversed by daily supplementation with 300 mg of PhospatidylSerine; in particular, verbal recall, long-term memory and overall cognitive functioning were improved.10,11

Daily dietary supplementation with 100 mg to 300 mg of PhospatidylSerine enhances human cognitive function and may interrupt, attenuate or arrest cognitive deterioration. This property of PhospatidylSerine was recognized by the U.S. Food and Drug Administration in its announcement of a Qualified Health Claim on May 13, 2003, that “Consumption of PhospatidylSerine may reduce the risk of dementia in the elderly” and “Consumption of PhospatidylSerine may reduce the risk of cognitive dysfunction in the elderly.”12 In making its determination, the U.S. Food and Drug Administration also endorsed the safety of daily dietary supplementation with up to 300 mg of phosphatidylserine.12

Next Best Kept Secrets to Healthy Aging topic:
Essential Brain Nourishment: Ginkgo biloba Leaf Extract

9. Villardita C, Grioli S, Salmeri G. Nicoletti F, Pennisi G. Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin Trials J 1987;24:84-93.
10. Palmieri G, Palmieri R, Inzoli MR, Lombardi G, Sottini C, Tavolato B, Giometto B. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J 1987;24:73-83.
11. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer’s disease. Psychopharmacol Bull 1992;28:61-66.
12. Taylor CL. Letter regarding phosphatidylserine and cognitive dysfunction and dementia. US Food and Drug Administration.

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