ResveraShots Resveratrol Super Formula

We’ve recently releases a brand new product, ResveraShots™ Resveratrol Super Formula.

ResveraShots™ is a cutting-edge dietary supplement featuring resVida®, a high potency form of Resveratrol, the key polyphenol found in red wine.  Delivered in a liquid matrix, each daily serving of Resverashots™ delivers 100 mg of 99% pure Resveratrol, infused with a proprietary 1,950 mg phytonutrient energy blend and 400 mcg of Chromax®.  Chromax® is a widely researched, clinically validated for of the essential element chromium.

Find out more about it here:
http://www.purityproducts.com/purityEcommerce/control/productDetail?productId=resverashots-resveratrol-super-formula&source=blog

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Polyphenols: More Reasons to Love Fruits and Vegetables

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Polyphenols – More Reasons to Love Fruits and Vegetables

Polyphenols are large molecules with very complex structures. While it’s their chemical complexity that makes polyphenols so biologically active in the human body, this feature also makes their absorption in the intestinal tract very inefficient. Some polyphenols (such as genistein and the soy isoflavones) must be processed by intestinal bacteria before they can be absorbed at all – meaning that a healthy colon is a prerequisite to obtaining health benefits from dietary polyphenols. A healthy colon needs lots of soluble dietary fiber – and there’s no better source of the best colon-friendly dietary fiber than the polyphenol-rich fruits and vegetables – whole or powdered. Then, after being absorbed, many polyphenols must be activated in the liver – another organ that must be in top shape before the health benefits of polyphenols can be maximized. As you may have guessed already, the best promoters and supporters of liver health and function are the polyphenol-rich fruits and vegetables.

The Bottom Line

The more fruits and vegetables you eat, the more polyphenols you enjoy. And, “enjoy” is the key concept here – polyphenols abound in fruits, vegetables, fruit juices, tea, coffee, red wine, chocolate and high-quality polyphenol-packed beverages and drinks made using cold-processed nutrient- and phytonutrientrich fruit and vegetable powders. Fruits (especially berries) and vegetables – natural healthpromoting foods packed with polyphenols, especially the bioflavonoids and anthocyanins – eat plenty every day.

Next Best Kept Secrets to Healthy Aging topic:
Hyaluronic Acid – The Molecule of Youth

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Polyphenols as Antioxidants

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Polyphenols as Antioxidants

Several polyphenols have direct antioxidant effects. Others are metabolized by bacteria in our intestines. These metabolites are absorbed into the bloodstream and they influence cell-signaling processes that lead to immune-supporting effects and free radical-scavenging effects. Polyphenols are the most abundant antioxidants in the diet. Typically, the total dietary intake of polyphenols is about 10 times higher than the intake of vitamin C and 100 times higher that the intakes of vitamin E and carotenoids. By themselves, the anthocyanins often contribute more than half of the total antioxidant activity of the diet.21

The polyphenols not only directly detoxify potentially oxidizing substances within the body, they increase the body’s inherent antioxidant defenses. For example, an important mechanism by which polyphenols enhance antioxidant defenses in the body is through stimulating the synthesis of glutathione, the major antioxidant enzyme within human cells.22 As antioxidants, polyphenols display a dual nature – directly blocking oxidation themselves and recruiting more natural defense systems into the fray.

A considerable body of scientific literature underlines the important role of combating oxidative stress in the maintenance of optimal cell, tissue, organ and body-wide healthy function. Although the complex relationships between antioxidant status and healthy aging are still poorly understood and are being studied intensively, it is clear that the polyphenolic phytonutrients protect cell constituents against oxidative damage by virtue of their powerful antioxidant potency. They also help prevent oxidation from occurring. New research findings published in Clinical Chemistry show that low-density lipoproteins (LDL) that have had resveratrol added to them by the liver are resistant to oxidation.23 Unoxidized LDL can be removed from the body safely without harm to the cardiovascular system.24

Our ability to increase our own antioxidant prowess was recently demonstrated by the results of a study published in the Journal of Nutrition.25 In this study, the greater the number of different fruits and vegetables in the diet, the more effective the mix was in improving the body’s antioxidant status. Women who ate on average 8 servings a day of a broad range of fruits and vegetables, providing an array of polyphenolic phytonutrients, increased their antioxidant status more than women who ate on average 9 servings a day of just a few fruits and vegetables. This finding reinforces the message that the more diverse and polyphenol-rich the diet, the healthier one is likely to be. It also speaks to the fact that one should consume a variety of brightly colored foods for health. After all, a variety of polyphenols are responsible for the range of beautiful, bright colors seen in fruits and vegetables.

Polyphenols can be the champions of your antioxidant defense system – and the more polyphenols you consume, the stronger your defenses.

Next Best Kept Secrets to Healthy Aging topic:
Polyphenols – More Reasons to Love Fruits and Vegetables

References:
21. Prior RL. Fruits and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr 2003;78:(Suppl.):570S-578S.
22. Moskaug JO, Carlsen H, Myhrstad MC, Blomhoff R. Polyphenols and glutathione synthesis regulation. Am J Clin Nutr 2005;81Suppl.):277S-283S.
23. Urpi-Sarda M, Zamora-Ros R, Lamuela-Raventos R, Cherubini A, Jauregui O, de la Torre R, Covas MI, Estruch R, Jaeger W, Andres- Lacueva C. HPLC-Tandem mass spectrometric method to characterize resveratrol metabolism in humans. Clin Chem 2007;53:292-299.
24. Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C, Visioli F, Distante A, De Caterina R. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: Antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol 2003;23:622-629.
25. Thompson HJ, Heimendinger J, Diker A, O’Neill C, Haegele A, Meinecke B, Wolfe P, Sedlacek S, Zhu Z, Jiang W. Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake. J Nutr 2006;136:2207-2212.

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Polyphenols: Bioflavonoids

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Bioflavonoids

The interactions between the members of a large sub-class of polyphenolic phytonutrients, the bioflavonoids, and human cells, tissues and organs have been studied in great depth. Many investigators have discovered and confirmed that when consumed in sufficient amounts, the bioflavonoids are positively associated with the health and function of many body systems.

The way some bioflavonoids work might be surprising. In many cases, they act to maintain the activation of normal body control mechanisms so that these systems do not go out of tune. Laboratory experiments have demonstrated that many bioflavonoids, such as quercetin in apples, fisetin in strawberries, epigallocatechin-3-gallate in green tea, galangin from flower pollen, hydroxycinnamic acid in broccoli and genistein in soy, maintain the internal life cycle regulation of the body’s cells. This helps the body comply with its needs for normal cell turnover, replacement and renewal as, over the years, the body experiences the physical and biochemical “wear and tear” of daily life. It is the best means the body has to “sweep out the old” and make room for the new.

As shown by the results of recent published studies, bioflavonoids foster normal life cycles in human cells.11,12,13 While abnormally long lifetimes may seem to mean healthier aging, in fact, normal life cycles help cells, tissues and organs stay healthy and fully functional longer – and in so doing, promote healthy aging. A normal life cycle for cells includes the process of living healthy and dying when their functionality and utility have come to an end. It is the process of normal life, repair, death and renewal of cells that leads to healthy organs and systems of the body. Thus, maintaining these normal processes is what leads to optimal health and an interruption of these functions can have disastrous consequences on the body.

Further benefits from increased dietary intake of bioflavonoids include the promotion of healthy cognitive function. In a recently completed and published study of rat brain functions fisetin (found in strawberries) was seen to increase the ability to recall old memories (by facilitating the process known as “long-term potentiation” with the hippocampus, the functional center of memory recall in rats and humans).14 This outcome probably resulted from the combination of properties of fisetin: antioxidant, cell function stabilizer and neural network enhancer.

Although not completely understood yet, the actions of another bioflavonoid, resveratrol (from grapes), within the brain contribute to the promotion of healthy brain longevity. As reported very recently in Bioorganic and Medicinal Chemistry resveratrol in the brain prevents the formation of molecular aggregates that interfere with information transmission between brain cells.15 By maintaining open channels of communication, resveratrol sustains healthy cognitive functioning.

Resveratrol also plays active roles in heart health. As shown in a report published recently in the Journal of Molecular and Cellular Cardiology resveratrol supports capillary function within the heart muscle, increasing the oxygenation of the muscle and its contractile efficiency.16

Recent studies highlight several distinct mechanisms whereby resveratrol can offer benefits to cardiovascular health. Studies show that resveratrol is an inefficient antioxidant in vitro, that is, in laboratory studies. However, when studied in vivo, i.e. in living systems, resveratrol shows an amazing ability to scavenge free radicals. Research suggests that the cardiovascular-protective effects stem from three major mechanisms of action: antioxidant, inflammatory-support and support of nitric oxide release. Nitric oxide release is necessary for enhancing circulation and supporting the health and integrity of blood vessels. These mechanisms lead to several distinct benefits that can be attributed to resveratrol supplementation. Some of these effects include protection of lipids from oxidative damage, supportive effects on normal heart rhythms, relaxation of blood vessels, which supports healthy circulation, and a reduction in free radical effects on cardiac tissue.17 Given these broad effects on cardiovascular health, resveratrol appears to hold promise as a polyphenol that provides long-term and comprehensive benefits for heart function.

Resveratrol is just one of the many heart-healthy polyphenols. The catechins in green tea are a subclass of polyphenols that includes epigallocatechin-3-gallate (EGCG) and that contribute to cardiovascular health by protecting the integrity of the interior lining of blood vessels. The results of a study published recently in Cardiovascular Research have shown that catechins function as antioxidants by inhibiting the secretion of certain enzymes by over-stimulated vascular smooth muscle cells which can be detrimental to the linings of blood vessels.18 EGCG and other catechins from tea also regulate the production of nitric oxide, stimulating blood vessel health and vasodilation, ultimately promoting circulatory function. By doing so, catechins enhance blood vessel function and structure.

Tea consumption has also been found to be protective of heart function over the long-term. Studies suggest that higher tea consumption leads to better protection of cardiac function with age. Tea contains numerous beneficial polyphenols, including the catechin EGCG. Furthermore, tea rich in EGCG has been shown to support circulation and promote antioxidant activity.19

Cranberries are similarly considered one of the more heart-healthy fruits because of their high polyphenol content. Surprisingly, cranberries have a higher amount of total polyphenols per serving than blueberries, apples, red grapes or strawberries.20 Cranberries are particularly high in flavonoids, and also contain a small amount of resveratrol. Research conducted on cranberries shows that they support the body’s antioxidant defenses and protect cholesterol molecules from free radical damage. Laboratory research using cranberry powder found that it stimulated the major cellular antioxidant systems including superoxide dismutase, catalase and peroxidase. Studies in humans have found that the polyphenolics in cranberries increase antioxidant nutrient levels in the blood, increasing the protection of the cardiovascular system.

Several polyphenols show cardiovascular and supportive effects by working as antioxidants, supporting the body’s normal inflammatory response, protecting lipids and cholesterol molecules from oxidative damage, and by directly influencing the function of the heart muscle. The consumption of a wide variety of polyphenolic compounds, including the ones mentioned above, can yield far-reaching benefits for cardiovascular wellness.

Next Best Kept Secrets to Healthy Aging topic:
Polyphenols as Antioxidants

References:
11. Yang JH, Hsia TC, Kuo HM, Chao PD, Chou CC, Wei YH, Chung JG. Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos 2006;34:296-304.
12. Lu X, Jung J, Cho HJ, Lim DY, Lee HS, Chun HS, Kwon DY, Park JH. Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. J Nutr 2005;135:2884-2890.
13. Murray TJ, Yang X, Sherr DH. Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. Breast Cancer Res 2006;8:R1 (doi: 10.1186/bcr1391).
14. Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERKdependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A 2006;103:16568-16573.
15. Riviere C, Richard T, Quentin L, Krisa S, Merillon JM, Monti JP. Inhibitory activity of stilbenes on Alzheimer’s ß-amyloid fibrils in vitro. Bioorg Med Chem 2007;15:1160-1167.
16. Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, Pant R, Menon VP, Otani H, Maulik N. Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. J Mol Cell Cardiol 2006 (doi:10.1016/j. yjmcc.2006.10.018).
17. Penumathsa SV, Maulik N. Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease. Can J Physiol Pharmacol. 2009;87(4):275-86.
18. El Bedoui J, Oak MH, Anglard P, Schini-Kerth VB. Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression. Cardiovasc Res 2005;67:317-325.
19. Wolfram S. Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr. 2007;26(4):373S-388S.
20. McKay DL, Blumberg JB. Cranberries (Vaccinium macrocarpon) and cardiovascular disease risk factors. Nutr Rev. 2007;65(11):490-502.

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Polyphenols: Anthocyanins

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Anthocyanins

Berries, especially blueberries, are known to be a good source of the polyphenol subclass known as anthocyanins. New research shows that the health benefits of the anthocyanins extend throughout the body.

In one of the more recent studies, the blueberry anthocyanin, pterostilbene, showed an ability to support the health of colon cells by protecting against the early loss of cellular regulation.6 Because colon health and function is so absolutely dependent on tight and well-managed cellular regulation, this finding demonstrates just how powerful the anthocyanins are as promoters, supporters and managers of colon health.

The abilities of the anthocyanins to beneficially manage, direct and redirect the functions of the body’s physiologic systems are not limited to any one (or even few) of those systems. Cognitive functions, all-important to healthy aging, are sustained and boosted by anthocyanins.

In tests using laboratory animals, anthocyanin-rich blueberry extract has been effective in protecting against age-related deficits in neuron-to-neuron signaling in the brain, with accompanying improvements in learning abilities.7 In one study, in which aging rats were fed a standard diet supplemented with blueberry extract for 8 to 10 weeks, performance on an objective test of learning and memory depended on how much of the anthocyanin compounds were found in the rats’ brains.8 In other words, those rats that ate the largest amount of anthocyanin-containing blueberry extract accumulated the most anthocyanins in their brains. These animals had the best learning capacity and were found to perform the most accurately on this standardized assessment.

Exciting new research has shown that anthocyanins also promote the healthy function of non-neuron cells in the brain. These cells support neural activity by protecting neurons from the damage that can be caused by environmental toxins, oxidizing byproducts of the normal intense level of metabolic activity in neurons or aberrant electrical signals. In short, these cells help maintain the health of the neurons. However, if they become over-stimulated they can harm the very cells they are responsible for protecting by promoting free radical generation. Research published in the Journal of Neuroscience Research shows that blueberry anthocyanins help the supporting cells modulate their activity level and the intensity of their responses to various stimuli.9 What this means is that anthocyanins support brain defenses and stabilize the brain’s internal environment. Further evidence for the neuroprotective benefits of blueberry anthocyanins comes from a study in which rats were either fed a diet rich in blueberries or were placed in a control group. The rats were then injected with a chemical into their brains that led to a significant impairment of learning performance. Although all rats had significant decreases in their learning abilities, the group of animals receiving the blueberry extract performed significantly better at standardized learning tasks. Imaging results on the brains of rats fed blueberries also revealed significant protection of neurons versus rats in the control group.10 Because of their high anthocyanin content, blueberries are therefore protective against the damaging effects of free radicals on brain cells.

Together, these findings indicate that the anthocyanins in blueberries are able to enter the bloodstream, travel to the brain and act within the brain to foster an internal environment that supports learning ability and memory retention – both highly desirable results for promoting healthy aging.

Next Best Kept Secrets to Healthy Aging topic:
Bioflavonoids

References:
6. Suh N, Paul S, Hao X, Simi B, Xiao H, Rimando AM, Reddy BS. Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 2007;13:350-355.
7. Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: Beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 2005;81(Suppl.):313S-316S.
8. Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela- Raventos RM, Joseph JA. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 2005;8:111- 120.
9. Lau FC, Bielinski DF, Joseph JA. Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharideactivated BV2 microglia. J Neurosci Res 2007 Jan 30 (doi: 10.1002/ jnr.21205).
10. Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, DeCabo R, Mouton PR, Shukitt-Hale B, Joseph JA, Ingram DK. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging. 2008;29(11):1680-9.

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Polyphenols in Healthy Aging

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Polyphenols and Polyphenols in Healthy Aging

Plants have been used as a health supporting tool since ancient times. The use of therapeutic botanicals transcends cultures. Traditional herbalists throughout the world spent time observing the phenomena presented by nature through the interactions plants had with predators and the varied conditions of their environments and discovered that plants were surprisingly adept at adapting to difficult situations. More often than not, plants found ways to survive and even thrive in harsh conditions. Putting two and two together, these observers found that what benefits plants, fruits and vegetables in their struggle to survive would also be beneficial for humans. These observations by great healers through the centuries have led to the explosion we’ve seen today in the use of herbal therapies to promote optimal health. Plants are full of health-promoting compounds including vitamins and minerals. But they contain compounds that are even more exciting in their potential to promote wellness – the class of compounds collectively known as polyphenols. That’s right! Polyphenols have been used to promote health since time immemorial. These compounds have been the backbone of the wisdom of traditional systems of medicine and it’s only now that modern science is beginning to untap the beneficial effects that nature has endowed these substances with.

You may have heard of some of the more highly publicized polyphenols, such as quercetin, hesperidin, resveratrol, epigallocatechin-3-gallate (“EGCG”), caffeine, genistein and the soy isoflavones, as well as the anthocyanins in berries. Others that you will be hearing much more about in the near future include fisetin, hydroxycinnamic acid and galangin from flower pollen. These are just a handful of the thousands of polyphenols that have been isolated. While polyphenols serve important roles in plants as a means of defense from predators, research is finding that these compounds have significant pharmacological activities.

Vitamins, minerals and other phytonutrients are amazingly talented craftsmen, sculptors, artists, engineers, communications experts and skilled technicians. Polyphenols, on the other hand, orchestrate, conduct, administer and direct the immense processes of life. They are increasingly recognized as the major active components in fruits and vegetables. As the individual polyphenols have been studied in detail, and compared to each other, it has become clear that each acts slightly differently in benefiting human health.1 The beneficial outcome of this integrated cooperation is a vastly greater robustness and versatility in our abilities to respond to health-challenging situations and environmental insults. Healthier responses lead to healthier aging.

Polyphenols in Healthy Aging

The scientific literature provides a feast of detailed evidence that very strongly documents the vital importance of polyphenols to vibrant health in all of its forms – tremendous and ever-increasing research highlights the effects of polyphenols in the areas of heart health, immune system health and strength, skeletal health and function, nervous system health and longevity, and blood glucose regulation. In all of these activities the polyphenols act as creative and sensitive managers, directing and redirecting cellular activities toward greater health. They are masters of cell signaling processes.

Most polyphenols interact directly with cell receptors or enzymes. These interactions trigger intracellular reaction pathways that work to multiply the potency of each polyphenol molecule. For example, as shown in research published recently in BMC Neuroscience, the polyphenolic soy isoflavones interact with estrogen receptors in brain cells to stimulate changes in DNA activation patterns.2 These interactions ultimately lead to potential cognitive benefits. Further evidence of the interaction of polyphenols with cell-signaling pathways comes from literature outlining the ability of these compounds to modulate the normal inflammatory process in the body. Research suggests that polyphenols interact with genes, proteins and enzymes in the body, in a fashion similar to a conductor of an orchestra, to support and maintain a healthy inflammatory response, preventing imbalances in this crucial component of the immune system. Unique to polyphenols is their ability to influence several cell-based pathways and molecules, making them important modulators of immune and inflammatory processes.3

Dietary polyphenols can exert their effects on intracellular reaction pathways separately, sequentially or in combination, and the effects of one polyphenol can complement and reinforce those of another. In fact, many investigators have reported that mixtures of polyphenols have profound effects on cardiovascular health, heart health, healthy blood pressure regulation, liver health and overall immune system strength.4,5 However, it is clear that the activities of these compounds are synergistic. More important than individual polyphenolic compounds is the combined effect of several. Clearly, the cooperative nature of the polyphenols overrides the properties of any individual superstar.

Next Best Kept Secrets to Healthy Aging topic:
Anthocyanins

References:
1. Jeong YJ, Choi YJ, Kwon HM, Kang SW, Park HS, Lee M, Kang YH. Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids. Br J Nutr 2005;93:581-591.
2. Bu L, Lephart ED. AVPV neurons containing estrogen receptor-beta in adult male rats are influenced by soy isoflavones. BMC Neurosci 2007 Feb 1;8:13 (doi:10.1186/1471-2202-8-13).
3. Santangelo C, Varì R, Scazzocchio B, Di Benedetto R, Filesi C, Masella R. Polyphenols, intracellular signalling and inflammation. Ann Ist Super Sanita. 2007;43(4):394-405. Review.
4. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005;81(Suppl.):317S-325S.
5. Peluso MR. Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. Exp Biol Med 2006;231:1287-1299.

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